Cook A, Hsia Y, Russell N, et al. - Researchers here examined concordance of early empiric antibiotic treatment in children and neonates using European Committee on Antimicrobial Susceptibility Testing interpretive guidelines. Using REDCap through the Global Antibiotic Prescribing and Resistance in Neonates and Children network from February 2016 to February 2017, they obtained data regarding patient characteristics, antibiotic treatment, microbiology, and 30-day all-cause outcome from children < 18 years with blood-culture-confirmed bacterial bloodstream infections (BSI) were collected. Twenty-five hospitals in 19 countries reported 452 children with blood-culture-positive BSI receiving early empiric antibiotics. Patients receiving a discordant early empiric antibiotic regimen were identified to have nearly 3-fold higher odds of mortality for confirmed pediatric BSI.