Nie C, Han X, Wei R, et al. - Researchers assessed blood-derived DNA methylation levels of two tumour-related genes, namely, ZNF331 (Zinc-finger protein 331) and WIF1 (Wnt-inhibitory factor-1), as well as their influences on the risk and prognosis of gastric cancer (GC). This analysis involved 398 GC cases and 397 controls. A follow-up of 5 years was performed for all cases. A significant reduction in GC risk was caused by high ZNF331 methylation, post-propensity score adjustment, which also presented in males. However, there was no link between WIF1 methylation and GC risk. GC prognosis remained unaffected by ZNF331 and WIF1 methylation. Overall, ZNF331 methylation in peripheral blood leukocytes may influence GC risk in conjunction with the intake of green vegetables and garlic and may behave as a potential biomarker of GC.