Sun L, et al. - Via this multi-institutional cohort study, researchers sought the survival outcomes in patients with cutaneous squamous cell cancer of the head and neck (cSCC-HN) with disease recurrence after surgery and postoperative radiotherapy. In addition, they determined how immune status is related to disease-related outcomes. Disease recurrence after surgery and postoperative radiotherapy was seen in 72 of the 205 patients in the original cohort. Outcomes suggest 1-year overall survival of 43.2% and median survival is 8.4 months after disease recurrence. Immunosuppressed and immunocompetent patients displayed no significant differences regarding the median survival (8.0 vs 12.9 months). Patients who were not open to surgical salvage had significantly lower median survival relative to patients who underwent surgical salvage (4.7 vs 26.1 months), regardless of immune status.