Rentz DM, Papp KV, Mayblyum DV, et al. - In clinically normal older adults (CN), this study was undertaken to ascertain if a digital clock-drawing test, DCTclock, is better than standard cognitive assessments for differentiating diagnostic groups and detecting biomarker evidence of amyloid and tau pathology. Researchers included a total of 300 participants from the Harvard Aging Brain Study and the PET laboratory at Massachusetts General Hospital to undergo the DCTclock, standard neuropsychological assessments including the Preclinical Alzheimer Cognitive Composite and amyloid/tau PET imaging. The outcomes indicated that in CN older adults, DCTclock differentiated between diagnostic groups and is better than traditional cognitive tests for detecting biomarkers of amyloid and tau pathology. The data demonstrated that validation of such digitized measures has the potential of providing an efficient tool for detecting early cognitive changes along the AD trajectory.