Tabung FK, et al. - Researchers used an empirical dietary index for hyperinsulinemia (EDIH; a food-based index that characterizes dietary insulinemic potential based on circulating C-peptide concentrations) in 46,210 men (Health Professionals Follow-Up Study, 1986–2012) and 74,191 women (Nurses’ Health Study, 1984–2012) to assess the links between hyperinsulinemic diets and colorectal cancer risk. Using food-frequency questionnaires, they assessed diet every 4 years to calculate EDIH scores. They calculated HRs and 95% CIs for colorectal, proximal/distal colon and rectal cancer risk using multivariable-adjusted Cox regression. They found 33%, 22%, and 26% higher risk of developing colorectal cancer related to higher EDIH scores when participants in the highest quintiles were compared with those in the lowest quintiles. Overall, the impact of dietary intake on colorectal cancer development may be partly attributed to the insulinemic potential of diet.