Cotton CH, Ahluwalia J, Balkin DM, et al. - Multiple anatomical sites and a large surface area were correlated with a higher risk, whereas S2 or parotid infantile hemangiomas (IHs) were related to a lower, but still potential, risk. Such findings may be useful in counselling families and making decisions about the evaluation of infants with large head and neck IHs.

• In total, 238 patients (mean [SD] age, 2.96 [4.71] months; 184 [77.3%] female) were involved in the analysis; 106 (44.5%) met the criteria for definite (n = 98) or possible (n = 8) PHACE syndrome.

• A stepwise linear regression model discovered that having a surface area of 25 cm ² or more and being involved in three or more locations were statistically significant risk factors for PHACE syndrome.

• A lower risk was associated with the involvement of the parotid gland and segment S2.

• Race and ethnicity may also be linked to PHACE syndrome risk, though more research is needed.