Oderiz CC, von Ellenrieder N, Dubeau F, et al. - Through a cohort study of 103 patients with focal drug-resistant epilepsy who underwent stereoelectroencephalography between January 1, 2007, and January 1, 2017, researchers evaluated whether removal of the seizure-onset zone resulting from cortical stimulation was related to a good surgical outcome. Cortical stimulation-induced seizures were present in 59 patients. In the good outcome group vs the poor outcome group, the percentage of patients with cortical stimulation-induced electroclinical seizures was higher. The percentage of the resected contacts encompassing the cortical stimulation–informed seizure-onset zone associated with surgical outcome. For spontaneous seizures, a comparable result was noted. Longer elapsed time since the most recent seizure was correlated with a greater probability of inducing seizures. Thus, seizure induction by cortical stimulation seems to recognize the epileptic generator as reliably as spontaneous seizures do and this finding might result in a more time-efficient intracranial presurgical investigation of focal epilepsy as the requirement to record spontaneous seizures is decreased.