Bae YS, Choi S, Lee K, et al. – In this cohort study involving 205,394 participants from the Korean National Health Insurance Service, researchers investigated the correlation of concurrent alterations of metabolic health and weight on cardiovascular disease (CVD) over time. Increased risk for CVD was noted in those who became metabolically healthy obese, metabolically unhealthy nonobese, and metabolically unhealthy obese, amongst initial metabolically healthy nonobese (MHNO), in comparison with those who remained MHNO. Conversely, improving metabolic health and obesity were linked to reduced CVD risk among initially metabolically unhealthy nonobese to secondary MHNO, metabolically unhealthy obese to MHNO , and metabolically unhealthy obese to metabolically healthy obese participants. Thus, modifications toward metabolically unhealthy or obese states led to an elevated CVD risk. Improving metabolic health along with decreasing weight may result in a reduced risk of CVD.