Kandraju H, Kanungo J, Lee KS, et al. - Researchers performed a retrospective study to assess the correlation of combined exposure to antenatal steroids and prophylactic indomethacin with the outcome of spontaneous intestinal perforation (SIP) among neonates born at < 26 weeks’ gestation or < 750 g birth weight. The sample consisted of preterm infants admitted to the Canadian Neonatal Network (CNN) units between 2010 and 2018. Infants were categorized into 2 groups based on antenatal steroid exposure; the latter sub-grouped as recent (≤ 7 days before birth) or latent (> 7 days before birth) exposures. Four thousand one hundred twenty-one (87%) of the 4,720 eligible infants received ANS, while 1,045 (22.1%) received PI. In preterm neonates of < 26 weeks’ gestation or birth weight < 750 g, co-exposure of ANS and PI was related to SIP, particularly if ANS was received within 7 days before birth. Among those who had not been exposed to ANS, PI was correlated with lower odds of mortality.