Orri M, et al. - Researchers aimed at investigating the association of childhood irritability and depressive/anxious mood profiles with adolescent suicidality. Outcomes suggested a higher suicidal risk during adolescence among children with high irritability and depressive/anxious mood and, to a lesser extent, with moderate irritability only compared with children with low symptom levels. Early manifestation of chronic irritability during childhood, especially when combined with depressive/anxious mood, may be associated with an elevated risk for adolescent suicidality. The putatively causal role of irritability should be investigated.