Goodman CR, et al. - Researchers performed an observational cohort study on women with FIGO stage III-IVA type 1 (grade 1–2, endometrioid) endometrial cancer (EC) who underwent hysterectomy and received multi-agent chemotherapy (CT) and/or radiotherapy (RT) from 2004 to 2014 at Commission on Cancer-accredited hospitals to estimate how sequence of adjuvant CT and RT relates with overall survival (OS) using propensity score-adjusted matched cohorts. They identified 5,795 women, of whom 1,260 (21.7%) received RT only, 2,465 (42.5%) received CT only, 593 (9.7%) received RT before CT, and 1,506 (26.0%) received RT after CT. They noted longer survival for women who received RT after CT vs those who received RT before CT or either as monotherapy. They recommend considering treatment with multi-agent CT before RT for inclusion as a treatment arm in future prospective trials.