Kern S, et al. – In this study involving 648 participants (mean age: 72.3 years), researchers analyzed the association of cerebrospinal fluid (CSF) neurofilament light (NFL) and neurogranin (Ng) levels with the risk of mild cognitive impairment (MCI), the consequent size of these markers in comparison with CSF total tau (T-tau) or phosphorylated tau (P-tau) for the risk of MCI, and also the impact of CSF amyloid-β (Aβ42) on these associations. They measured the CSF NFL and Ng levels using an in-house sandwich enzyme-linked immunosorbent assay. They also calculated the CSF Aβ42, T-tau, and P-tau levels with automated electrochemiluminescence immunoassays. They noted an association of top quartile of CSF NFL with a 3.1-fold increased risk of MCI compared with the bottom quartile. No interaction between Aβ42 and CSF NFL was observed for the risk of MCI.