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Association of central noninvasive brain stimulation interventions with efficacy and safety in tinnitus management: A meta-analysis

JAMA Otolaryngology-Head & Neck Surgery Sep 22, 2020

Chen JJ, Zeng BS, Wu CN, et al. - In this meta-analysis of 32 unique studies involving 1,458 unique participants (mean female proportion, 34.4% [range, 0%-81.2%]; mean age, 49.6 [range, 40.0-62.8] years; median age, 49.8 [interquartile range, 48.1-52.4] years), researchers sought to explore the connection between different central noninvasive brain stimulation (NIBS) therapies and effectiveness and acceptability for the treatment of tinnitus. The findings of the network meta-analysis showed that cathodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex combined with transcranial random noise stimulation over the bilateral auditory cortex has been correlated with the greatest improvement in tinnitus severity and quality of life relative to the controls. Repetitive transcranial magnetic stimulation with priming had a superior beneficial correlation with tinnitus severity relative to the strategies without priming. The data presented in this work showed a potential role of NIBS interventions in tinnitus management.

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