Pornpattananangkul N, et al. - Researchers performed this large-scale cross-sectional functional magnetic resonance imaging study that included 2878 children to determine how the brain functions in children with anhedonia map onto intrinsic and task-related brain imaging measures. Outcomes revealed the association of anhedonia (but not low mood, anxiety, or attention-deficit/hyperactivity disorder) with hypoconnectivity at rest between the ventral striatum and the cingulo-opercular network and with hypoactivation during reward anticipation in the dorsal striatum and cingulo-opercular network. Mapping thereby revealed perturbed intrinsic reward arousal integration and diminished extrinsic reward anticipation activity in anhedonia in children.