Long L, Liu X, Jin L, et al. - Researchers investigated the impact of bowel movement frequency on the risk of developing hepatocellular carcinoma (HCC). For this purpose, a total of 88,123 women in the Nurses' Health Study and 28,824 men in the Health Professionals Follow-up Study were followed for up to 24 years. Overall 101 incident HCC cases were reported. A higher risk of developing HCC was observed in participants with bowel movement more than once daily vs those with daily bowel movements. These observations are required to be corroborated and potential mechanisms underlying this link need to be unveiled.