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Association of blood n-3 fatty acid with bone mass and bone marrow TRAP-5b in the elderly with and without hip fracture

Osteoporosis International Feb 10, 2019

Kim BJ, et al. - in this case-control and cross-sectional study, researchers estimated 72 elderly candidates to analyze the relationship of blood n-3 fatty acid with bone mass and bone marrow (BM) tartrate-resistant acid phosphatase (TRAP)-5b in the elderly with and without hip fracture (HF). They noticed 26.2% lower plasma n-3 levels in subjects with HF as compared to those with osteoarthritis. They also found an association of standard deviation increment in plasma n-3 with a multivariate-adjusted odds ratio of 0.40 for osteoporotic HF. A higher plasma n-3 level was also associated with elevated bone mass at lumbar spine and total femur. They significantly found an inverse relation of plasma n-3 level with TRAP-5b level, but not with the bone-specific alkaline phosphatase level, in BM aspirates.
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