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Association of autofluorescence-based detection of the parathyroid glands during total thyroidectomy with postoperative hypocalcemia risk: Results of the parafluo multicenter randomized clinical trial

JAMA Surgery Nov 14, 2019

Benmiloud F, Godiris-Petit G, Gras R, et al. - Researchers examined how parathyroid preservation and postoperative hypocalcemia are influenced by intraoperative imaging systems using near-infrared autofluorescence light to identify parathyroid glands. They conducted a randomized clinical trial including 241 adults who had undergone total thyroidectomy. The temporary postoperative hypocalcemia rate lowered from 22% to 9% and the parathyroid autotransplantation and parathyroid inadvertent resection rates lowered from 16% to 4% and 14% to 3%, respectively, when near-infrared autofluorescence was used during total thyroidectomy. These findings support the utility of near-infrared autofluorescence–based identification of parathyroid glands during thyroid surgery in limiting parathyroid risk.
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