Montastruc F, et al. - In this population-based cohort study, whether switching to or adding aripiprazole is associated with serious psychiatric treatment failure compared with switching to or adding another antipsychotic drug in patients previously exposed to antipsychotic medications was investigated in this population-based cohort study. Outcomes suggest that switching to or adding aripiprazole could be associated with psychiatric worsening in some patients, but did not associate with psychiatric hospitalization, self-harm, or suicide when compared with another antipsychotic medication.