Shatwan IM, et al. - Experts probed into the tie-up between 2 single nucleotide polymorphisms (SNPs) at lipoprotein lipase (LPL), 7 tagging SNPs at the APOE gene, and a common apolipoprotein E (APOE) haplotype (2 SNPs) with blood lipids. Furthermore, they analyzed the interaction of these SNPs with dietary factors in individuals from the Prevention of Cancer by Intervention with Selenium (PRECISE) study. Data did not disclose any association between dietary factors and blood lipids after Bonferroni correction and adjustment for confounding factors in either cohort. It was deduced that genetic variations at the APOE locus affected plasma total cholesterol concentrations.