Chauhan N, et al. - In this cross-sectional study, researchers studied whether there is an association between apical periodontitis (AP) and cardiovascular disease (CVD) using noninvasive methods (ie, flow-mediated dilatation [FMD] and carotid intima-media thickness [c-IMT]). The study sample consisted of 120 men between 20 and 40 years old free from periodontal disease, CVD, and traditional cardiovascular risk factors. Using the Mann-Whitney U test and the Spearman rank correlation (r_s) test, data were analyzed. Compared to healthy controls, FMD was found to be significantly impaired in AP patients. In addition, the investigation shows statistically significant differences between c-IMT of the AP and control groups. A significant inverse correlation was observed between c-IMT and FMD. In subjects with AP, impaired FMD and increased c-IMT suggest a potential association between endodontic infection and CVD.