Chauquet S, Zhu Z, O’Donovan MC, et al. - In this genetic association study performed using a 2-sample mendelian randomization analysis, researchers aimed to determine the potential effect of different antihypertensive drug classes on schizophrenia, bipolar disorder, and major depressive disorder. They herein assessed the correlation between a single-nucleotide variant (SNV) and drug target gene expression retrieved from prior expression quantitative trait loci (eQTL) data in blood (sample 1) and the SNV-disease correlation from published case-control genome-wide association studies (sample 2). Per findings, lower angiotensin-converting enzyme messenger RNA and protein levels have adverse association with schizophrenia risk. Researchers support greater pharmacovigilance and conducting further exploration into the effect of ACE inhibitors, especially those that are centrally acting, on psychiatric symptoms in patients with schizophrenia, as well as the role of ACE inhibitor use in late-onset schizophrenia.