Almuwaqqat Z, et al. - Among participants (n=2,027) from the Atherosclerosis Risk in Communities study, researchers investigated the risks of cardiovascular disease (CVD) events in relation to treatment with selective serotonin reuptake inhibitors (SSRIs) vs tricyclics and other non-SSRI antidepressants. Participants had a mean age of 63±10 years, 29% were men, and 78% were white; all received antidepressants at some time between 1987 and 2013. According to the findings, the use of SSRI vs non-SSRI antidepressant was not related to an attenuated risk of incident CVD. Overall, there was no evidence to support of the use of SSRIs vs tricyclics and other non-SSRI antidepressants in relation to reduced CVD risk.