Karcutskie CA, et al. - This work was planned to assess whether dosing of enoxaparin sodium based on peak anti-Xa levels is associated with the venous thromboembolism (VTE) rate after trauma. Researchers observed no reduction in rates of VTE with anti-Xa–guided dosing, and almost half of the patients never reached prophylactic anti-Xa levels; achieving those levels did not decrease VTE rates. Thus, they identified a necessity for other targets, such as platelets, to optimize thromboprophylaxis after trauma.