Hanseeuw BJ, et al. - Through a longitudinal prospective cohort study of 279 clinically normal participants, the contributors intended to determine the correlations measured during different observation periods for 7 years between amyloid-β (Aβ), tau, and cognition. A close link among tau-positron emission tomography (tau-PET), neuronal injury and cognition may be found. Mediated by successive changes in Aβ and tau when measured post 7 years, an association between initial Aβ and final cognition was assessed. For clinical criteria of mild cognitive impairment, persistent changes in normal older adults were identified from Aβ to tau to cognition. To track disease progression and to detect the earliest Alzheimer disease pathologic changes, repeated tau-PET observations and amyloid-PET observations respectively were crucially concluded.