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Association of adverse hearing, growth, and discharge age outcomes with postnatal cytomegalovirus infection in infants with very low birth weight

JAMA Dec 13, 2019

Weimer KED, et al. - In this multicenter retrospective cohort study of 304 infants with very low birth weight (VLBW) and postnatal cytomegalovirus (CMV) infection from January 1, 2002, through December 31, 2016, experts ascertained the risk for failed hearing screen, progressed postnatal age at discharge, or reduced growth at discharge in VLBW infants with postnatal CMV infection in comparison with CMV-uninfected infants and to contrast the risk for other major outcomes of prematurity, including bronchopulmonary dysplasia (BPD) and necrotizing enterocolitis (NEC), in children with and without postnatal CMV infection. The analysis validated a heightened risk of BPD, formerly reported on infants from this cohort from 1997 to 2012, however, it was not an extended risk of NEC following postnatal day 21. Results imply that postnatal CMV infection is related to lasting sequelae in the hearing and growth status of VLBW infants and with prolonged hospitalization.
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