Harris BN, et al. - In this multi-institutional study, researchers analyzed 349 cases to evaluate the relation of adjuvant radiation therapy with survival in subjects with advanced cutaneous squamous cell carcinoma (CSCC) of the head and neck at 2 tertiary referral centers from January 1, 2008, to June 30, 2016. More inclination towards adjuvant radiation therapy was observed among candidates with larger, regionally metastatic, poorly differentiated tumors with perineural invasion (PNI) as well as younger immunosuppressed cases. Lower overall survival (OS) was noticed among immunosuppressed patients and those with N2 or greater nodal disease. Overall, they concluded that adjuvant radiation therapy was associated with an improved OS for the entire cohort.