Fan BJ, Bailey JC, Igo RP, et al. - In this cross-sectional study, experts aspired to explore whether a genetic risk score (GRS) that comprised 12 primary open-angle glaucoma (POAG) genetic risk variants was correlated with age at disease diagnosis. Findings suggested that each higher GRS unit was linked to an earlier age at diagnosis, and affected people in the top 5% of the GRS had an earlier age at diagnosis vs those in the bottom 5% GRS. On average, a diagnosis of disease, people with POAG with the highest GRS had an earlier age of 5.2 years. These outcomes suggest that aggregate variants of genetic risk for POAG can affect clinically relevant disease features such as diagnostic age.