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Association between tumor acidity and hypervascularity in human gliomas using pH-weighted amine chemical exchange saturation transfer echo-planar imaging and dynamic susceptibility contrast perfusion MRI at 3T

American Journal of Neuroradiology Jun 18, 2019

Wang YL, et al. - In patients with gliomas, researchers studied the connection between pH-sensitive amine chemical exchange saturation transfer echoplanar imaging (CEST-EPI) and relative cerebral blood volume (CBV) measurements obtained from dynamic susceptibility contrast (DSC) perfusion MRI. Between 2015 and 2018, 90 patients with histologically confirmed gliomas were scanned. According to this retrospective study, a positive linear association between CBV and acidity was observed across patients in areas of T2-hyperintense, which is non-enhancing but not enhancing tumor. Within individual tumors, local heterogeneity was noted.
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