Beshara A, et al. - Researchers conducted a retrospective cohort study (2011–2013) within the Clalit Health Services, Israel in order to ascertain the time to colonoscopy following a positive guaiac-based fecal occult blood test (gFOBT) result. In addition, they investigated its association with the risk of overall colorectal cancer (CRC) and advanced-stage disease at diagnosis. Among 17,958 patients with positive gFOBT results, 685 cases of CRC were identified; an advanced-stage disease was diagnosed in 156 cases. At 0–3, 4–6, 7–9, 10–12 and 13–24 months, the rate of cancer diagnosis was 3.9%, 2.5%, 3.5%, 4.2% and 7.3%, respectively. they observed higher risks for any CRC and advanced stage disease for a colonoscopy follow-up of 12–24 months vs colonoscopy follow-up within 0–3 months. An increased risk starts at 10 months for right-sided cancer (n = 194). They noted the significant association of a result of 3–6 positive fields with the diagnosis of cancer and advanced stage disease. These findings emphasize encouraging an early uptake of colonoscopy and targeting those with 10–24 months delay and a 3–6 positive fields.