Cournoyer A, et al. - In this prospective cohort study conducted in a tertiary care academic urban hospital, researchers assessed the inter-device agreement of 2 tissue oximeters in relation to the quantity of subcutaneous fat (assessed by skinfold thickness). Participants included healthy volunteers. Using 2 tissue oximeters, the INVOS 5100C and the EQUANOX 7600, patients' tissue saturations and skinfold thickness were measured at 4 different sites (shoulder, forearm, knee, and calf) on both sides of the body. Findings revealed the correlation between the quantity of subcutaneous fat and the inter-device agreement of the 2 studied oximeters. In the scenario of placement of sensors on sites with a significant quantity of subcutaneous fat, great care should be exercised while interpreting the monitoring using tissue oximetry. The way that appeared the most secure one to use that technology for the monitoring of critically ill patients was following the variations of saturations at the same peripheral site, in addition to the monitoring of cerebral oximetry.