Ngamdu ES, Adewale OO, Mallawaarachchi I, et al. - Researchers Hispanics with HIV infection for the associations between carotid artery intima-media thickness (CIMT), conventional cardiovascular diseases (CVD) risk factors, and HIV-related risk factors. In this cross-sectional study, 96 consecutive HIV patients on stable antiretroviral therapy and without history of CVD in a university-based outpatient clinic who underwent carotid ultrasound evaluation were included. Of 96 included Hispanic Americans (aged 39.7 ± 11.9; 89% men), 64% were on a protease inhibitor, and 11% had increased CIMT. Univariable analysis revealed significant association of increased CIMT with older age, metabolic syndrome, intermediate/high Framingham risk score, HIV infection duration ≥ 5 years, integrase inhibitors, and protease inhibitors. Multivariable analysis revealed independent correlation of only Framingham risk score with increased CIMT. Patients with intermediate/high Framingham risk score had significantly greater median common carotid artery–CIMT value compared with those with low Framingham risk score. In conclusion, increased CIMT is significantly associated with Framingham risk score and hence, they strongly recommend adherence to prevention guidelines to reduce CVD risk factor burden in this population.