According to findings, a mild to moderately decreased estimated glomerular filtration rate (eGFR) was not linked with brain atrophy in Alzheimer’s Disease Neuroimaging Initiative (ADNI) participants.

• Using cross-sectional data from the ADNI, an NIH-funded multicenter longitudinal cohort study, researchers sought to further understand the link between eGFR and brain volumes.

• This study included 1,596 participants who were 74 ± 7 years old with a mean eGFR of 69.4 ± 14.8 mL/min/1.73 m ² ; 53% with mild cognitive impairment, and 19% had dementia.

• In unadjusted analysis, a link was found between lower eGFR and smaller brain volumes.

• No link existed between eGFR and brain volumes, post-adjustment for age, gender, and education.

• These findings continued to be consistent following subgroup analysis by age stratification and baseline cognitive status.

• Age was a confounding variable in the unadjusted link between the eGFR and brain volumes.