Zheng PF, et al. - Researchers assessed the risk of coronary artery disease (CAD) and ischemic stroke in relation to the XK related 6 gene (XKR6) rs7819412 single nucleotide polymorphism (SNP) and serum lipid profiles. Using Snapshot technology, they obtained the genetic makeup of the XKR6 rs7819412 SNP in 1,783 unrelated Han Chinese. Differences in the genotypic frequencies of the SNP were found between CAD (GG, 81.0%; GA/AA, 19.0%) or ischemic stroke (GG, 81.2%; GA/AA, 18.8%) patients and healthy controls (GG, 85.7%, GA/AA, 14.3%; p < 0.05 vs CAD or ischemic stroke; respectively). Findings revealed the association of the XKR6 rs7819412 A allele with increased serum triglyceride levels in CAD, total cholesterol levels in ischemic stroke patients, and high risk of CAD and ischemic stroke.