Vyas MV, Wang JZ, Gao MM, et al. - Sequelae of stroke include poor mental health and depression, so researchers aimed at determining if stroke is linked with subsequent risk of suicide. By systematically searching MEDLINE, Embase, PsycINFO, and Google Scholar from inception to September 15, 2020, they screened 4,093 articles. Of these, they identified 23 studies of fair quality as eligible for inclusion, which included over 2 million stroke survivors, of whom 5,563 attempted suicide or died by suicide. Based on findings, they emphasize that stroke may be a risk factor for suicide. The pooled adjusted RR of suicide in stroke survivors was 1.73 vs the nonstroke group, with a significantly higher adjusted risk of suicide attempt than of death by suicide. A longer follow-up time in cohort studies was associated with a lower risk of suicide. In order to lower the burden of suicide in stroke survivors, comprehensive strategies to screen and treat depression and suicidal ideation in stroke survivors are needed.