Qian Y, Xie L, Li L, et al. - Researchers sought to determine single nucleotide polymorphisms (SNPs) in genomic regions related to sex hormone‐binding globulin (SHBG) levels that contributed to never‐smoking female non‐small cell lung cancer (NSCLC). Using a genome‐wide association meta‐analysis and gene expression profiles of Chinese females with NSCLC who never smoked, experts selected candidate genes. Experts found candidate SNP rs12233719 and rs7439366 both in candidate gene UGT ₂ B ₇ , which could be associated with circulating SHBG levels as well as cancer risk after starting with 12 genomic regions related to circulating SHBG levels and gene expression profiles from these participants. Female NSCLC patients’ tumor tissues exhibited upregulation of UGT2B7, and a correlation was identified between UGT2B7 and a poor prognosis in NSCLC. Overall, findings demonstrated an association of SNP rs12233719, which is associated with sex hormone regulation, with never‐smoking female lung cancer risk, which might explain, in part, NSCLC‐susceptibility in Chinese females.