Jimenez MC, et al. - Higher levels of total testosterone and lower levels of sex hormone-binding globulin (SHBG) have been linked to increased blood pressure (BP) in women, while an inverse relationship has been reported between total testosterone and BP among men. For this study, researchers focused on relationships among 24-hour ambulatory blood pressure (ABP), blunted nocturnal BP decline or the role of dehydroepiandrosterone sulfate (DHEAS), a forerunner to androgens. Participants were 229 normotensive men (≥50 years) and women (≥55 years) participating in the VITamin D and OmegA-3 TriaL. The link between each sex hormone and measures of BP and 24-hour ABP was determined by using sex stratified linear regression models adjusted for age, race/ethnicity, BMI, smoking and alcohol. Using logistic regression, associations with blunted nocturnal decline (>10% reduction in SBP or DBP during sleeping hours) were assessed. Findings revealed statistically significant inverse cross-sectional links between total testosterone and SHBG with seated DBP, and a significant positive association with DHEAS levels, observed in men only. Among women, no significant links were seen.