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Association between serum uric acid and bone health in adolescents

Osteoporosis International Jul 10, 2019

Karimi F, et al. - Via a cross-sectional study carried out on 413 (221 girls and 192 boys) Iranian adolescents aged 9–19 years, the researchers intended to examine the relationship between serum uric acid (UA) levels, which could be linked to bone health, and bone mineral density (BMD) in Iranian adolescents. An analysis of anthropometric, biochemical parameters and bone density was conducted on the individuals that involved serum UA, calcium, phosphorus, alkaline phosphatase, albumin, and vitamin D. A meaningful association between UA and bone parameters were reported by a Pearson correlation analysis. Serum UA was demonstrated to be correlated with BMD and bone mineral content at all sites, in multiple regression analyses adjusted for potential confounders. No association among UA, serum calcium and vitamin D concentrations could be ascertained. Hence, through this first research on adolescents, it was exhibited that a higher bone density was seen in those who had higher UA levels.
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