Yuwaki K, et al. - In a Japanese cohort, researchers investigated all-cause and non-liver disease mortality according to levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyltransferase (GGT) stratified by hepatitis virus infection status. In 1993-1994, participants were 7243 men and 13,513 women (aged 40-69 years) at the baseline survey. Two thousand, two hundred thirty-five deaths in men and 1901 deaths in women were identified during follow-up. Findings suggested a positive association of serum liver enzyme levels with all-cause mortality in participants without hepatitis virus infection. Similar associations for non-liver disease mortality have also been found.