Zhu Z, Wang A, Guo D, et al. - Given that high serum hepatocyte growth factor (HGF) levels raise ischemic stroke risk and are seemingly related to consequences following ischemic stroke, researchers used data from the CATIS (China Antihypertensive Trial in Acute Ischemic Stroke) to investigate if the link between HGF and ischemic stroke prognosis can be altered by blood lipid status. In 3,027 ischemic stroke patients, measurements of baseline serum HGF levels were obtained. A combination of death and major disability (modified Rankin Scale score ≥ 3) at 2 years post-ischemic stroke was considered as the primary outcome. For patients with dyslipidemia and for those with normal lipids, the odds ratios of primary outcome related to the highest tertile of HGF were estimated to be 2.13 and 0.81, respectively, after multivariate adjustment. Findings revealed a modified impact of blood lipid status on the link between serum HGF and ischemic stroke prognosis. A link was identified between raised serum HGF and outcomes in ischemic stroke patients with dyslipidemia, especially low HDL-C.