Hirvasniemi J, et al. - This article is composed with the goal to examine the connection between radiograph-based subchondral bone structure and cartilage composition evaluated with delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC) and T2 relaxation time. The outcomes of this study support the presumption that several tissues are influenced in early osteoarthritis (OA). Moreover, they indicate that the detailed investigation of radiographs may serve as a complementary imaging tool for OA studies.