Han W, et al. - In patients with symptomatic knee osteoarthritis (OA), researchers characterized the cross-sectional and longitudinal associations between quantitative measures of an infrapatellar fat pad (IPFP) signal-intensity alteration and knee structural abnormalities. A total of 261 symptomatic knee OA patients were selected from a 2-year follow-up randomized controlled trial. Using validated measures, cartilage volume and defects and bone marrow lesions were assessed. Baseline percentage^H and clustering-factor^H have been positively and significantly related to tibiofemoral bone marrow lesions increases over two years. In the tibiofemoral compartment, quantitative measurements of increased signal intensity in the IPFP were associated with structural knee abnormalities, suggesting that these measurements could be used as an additional entry criterion to enrich studies for faster knee OA progressors.