Wei X, et al. - Researchers explored the link between probiotic supplementation and asthma incidence in infants by analyzing 19 randomized controlled trials involving 5,157 children. These studies were identified from PubMed, Cochrane library, and EMBASE databases systematically searched from the inception dates to August 2018 and report the impacts of probiotic supplements vs placebo on asthma or wheeze incidence in infants. Using the Mantel-Haenszel statistical method, risk ratio and 95% confidence interval were calculated. In infants, a lower risk of asthma was not observed in association with the use of probiotic supplementation vs placebo. A significantly attenuated wheeze incidence was observed in relation to probiotics use among infants with atopy disease, as seen in subgroup analysis by asthma risk, but no significant links were found in the other subgroup analyses by participants receiving the intervention, timing of intervention, prevention regimen, probiotic organism, duration of intervention, and duration of follow-up. Overall, use of probiotics in the prevention of asthma in infants was not supported.