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Association between preterm birth and arrested cardiac growth in adolescents and young adults

JAMA Cardiology Aug 23, 2020

Goss KN, Haraldsdottir K, Beshish AG, et al. - Using cardiac magnetic resonance imaging (MRI), researchers conducted this cross-sectional study to describe cardiac structure and function in adolescents and young adults born preterm. This investigation was carried out at an academic medical center. The sample consisted of adolescents and young adults born moderately to extremely premature (20 in the adolescent cohort born from 2003 to 2004 and 38 in the young adult cohort born in the 1980s and 1990s) and 52 age-matched candidates who were born at term and had cardiac MRI. Cardiac strain analyses showed a hypercontractile heart, primarily in the right ventricle, in adults born prematurely. According to the findings, adolescents and prematurely born young adults had a statistically significantly smaller biventricular cardiac chamber size and reduced cardiac mass. Although function has been preserved in both age groups, such morphologic variations can be related to elevated lifetime cardiovascular disease risk following premature birth.

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