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Association between prenatal valproate exposure and performance on standardized language and mathematics tests in school-aged children

JAMA Neurology Feb 26, 2018

Elkjaer LS, et al. - The intention of the experts was to evaluate the tie-up between long-term school performance and prenatal exposure to valproate and a number of other antiepileptic drugs (AEDs) in children. Results shed light on the link between maternal use of valproate with a substantial decrease in school performance in offspring compared with children unexposed to AEDs and children exposed to lamotrigine. Hence, caution was recommended against the use of valproate among women of childbearing potential.
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