Cai L, Wu W, Lin L, et al. - Since irisin's role in maternal glucose metabolism and how it would react to dietary n‐3 polyunsaturated fatty acid (n‐3 PUFA) intake remains unclear, researchers investigated whether maternal plasma irisin is correlated with glucose metabolism and whether this association is affected by dietary n‐3 PUFA. The sample consisted of 932 pregnant women (20–28 weeks’ gestation) aged 20–45 years. Using a validated quantitative food frequency questionnaire, dietary n‐3 PUFA was estimated. Findings suggested that maternal plasma irisin was negatively correlated with HOMA‐IR (homeostatic model assessment of insulin resistance) and positively related to HOMA‐IS (homeostatic model assessment of insulin sensitivity), which was more pronounced in pregnant women who had higher intakes of n‐3 PUFA. Dietary n‐3 PUFA may play a role in altering the potential impact of maternal plasma irisin on HOMA‐IR and HOMA‐IS.