Tao LX, et al. - Researchers performed a cross-sectional and longitudinal analysis of the causal link between plasma homocysteine (Hcy) levels and the risk of hypertension by analyzing data from the Beijing Health Management Cohort study, which conducted routine health check-ups from 2012 to 2017. Findings of the cross-sectional analysis using the traditional definition of hypertension and the 2017 hypertension definition revealed that the risk of hypertension increased with Hcy levels, after adjusting for potential confounders. In the third quartile of Hcy, an increased risk of hypertension was shown in the longitudinal analysis. Overall, findings suggested the potential utility of elevated total plasma Hcy as a predictive biomarker for hypertension. When issuing precise precautions, gender-specific mechanisms were recommended to be taken into account.