Tao LX, et al. - Researchers conducted this cross-sectional and longitudinal analysis to examine the causal association of plasma homocysteine (Hcy) levels with the risk of hypertension. The investigators analyzed data from the Beijing Health Management Cohort study, which conducted routine health check-ups from 2012-2017. For the cross-sectional analysis and for the longitudinal analysis, they used multivariate logistic regression and a quadratic inference function approach, respectively. Findings revealed an increased hypertension risk in the third quartile of Hcy in the longitudinal analysis. For the prediction of hypertension, findings revealed that elevated total plasma Hcy could be used as a biomarker. The authors suggested that further attention should be paid to sex-specific mechanisms when issuing precise precautions.