Huang J, Lu X, Lin J, et al. - Researchers undertook a retrospective cohort analysis, wherein, they analyzed 8,501 patients who underwent their first controlled ovarian stimulation (COS) cycles with a freeze-all strategy, to investigate the link between peak serum estradiol level during COS and neonatal birthweight in freeze-all cycles. The participants delivered live-born singletons in subsequent frozen-thawed embryo transfer cycles. The participants were recruited from a tertiary-care academic medical center. As per the findings, there appeared no adverse effects of hyperestrogenic milieu during COS on neonatal birth weight following frozen-thawed embryo transfer, which affords reassuring information for high ovarian responders in freeze-all cycles regarding their offspring’s health.