Hori Y, et al. - Via retrospectively examining data from 62 individuals, researchers sought to assess the combination of tumor budding and depth (BD model) and worst pattern of invasion (WPOI) as histopathological prognostic factors in clinical N0 early oral tongue carcinoma. Associations have been assessed between histopathological factors (differentiation, stage, lymphatic invasion, blood vessel invasion, WPOI, and BD model) and regional control (RC) or disease-free survival (DFS). Data reported that the five-year RC and DFS rates, respectively, were 74% and 65%. Univariate analysis recognized blood vessel invasion, lymphatic invasion, WPOI, and BD model, on the other hand, multivariate analysis identified WPOI, and BD model, as predictive factors for RC. Univariate analysis recognized lymphatic invasion, WPOI, and BD model, while multivariate analysis identified WPOI, as predictive factors for DFS. When assessing the follow-up plan for patients with clinical N0 early oral tongue carcinoma, the patterns of pathological invasion should be considered.