Zoet GA, et al. - In parous women, researchers evaluated time-dependent changes in cardiometabolic health vs nulliparous women. Data of 2,459 women were studied who were part of the Prevention of Renal and Vascular End-stage Disease study, a population-based prospective longitudinal cohort for evaluation of cardiovascular disease (CVD) and renal disease in the general population. Women who were ≥40 years old at the initial visit were selected, who during the four follow-up visits reported no new pregnancies. Higher parity was linked to higher body mass index, lower high-density lipoprotein cholesterol and higher cardiovascular risk factor prevalence, which was consistent over time. For prospective research evaluating determinants of cardiometabolic health at an earlier age, these findings warrant understanding the role of pregnancy in women's CVD development.